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The primary cause of obesity is excessive food intake
However, rapid weight loss itselfespecially loss exceeding 1-2 pounds weeklycan temporarily shift thyroid hormone metabolism and TSH levels, a phenomenon called weight-loss-related thyroid adaptation
GLP-1 medications delay gastric emptying, meaning stomach contents may remain present longer than expected even after appropriate fasting
Patients with active or poorly controlled Crohn's disease face higher risks of adverse gastrointestinal effects from GLP-1 therapy
