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This difference is not coincidental: semaglutide is a specific amino acid sequence that activates GLP-1 receptors in the brain and gut, triggering measurable reductions in hunger hormones and calorie intake

Understanding whether expired GLP-1 medications are still usable applies the same logic to tirzepatide

The SUSTAIN trial series showed that patients receiving ongoing semaglutide maintained 80% or more of their initial weight loss over three years, compared to rapid regain in placebo groups

DOI: 10.1056/NEJMoa2403664

As a result, many are turning to aesthetic solutions like dermal fillers, skin-tightening treatments, or collagen-stimulating procedures to restore lost volume