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The Phase 2 data provides clear benchmarks: By week 4, most participants noticed reduced appetite and initial scale movement averaging 2-3% body weight reduction

Available online at: [Google Scholar] 26.Shim JS, Oh K, Kim HC

the body's sensitivity to insulin is reduced, so that the biological effect of insulin on target organs is reduced and glucose uptake and utilization are reduced, thus failing to maintain blood glucose stability
1.8 mg n = 30) without diabetes following 5 weeks treatment (titrated from 0.6 mg subcutaneously and increased in increments of 0.6 mg per week, up to end doses of 1.8 and 3.0 mg)

Tirzepatide is the better-characterized starting point because more public PK data exist
