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thus, initial interest focused on glucagon antagonism as antihyperglycaemic therapy [68]

Every 5 kg of weight loss independently reduces systolic blood pressure by approximately 3 to 5 mmHg, reduces triglycerides, improves HDL cholesterol, reduces insulin resistance, decreases systemic inflammation, and reduces mechanical strain on the heart

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These critical modifications confer a slightly higher affinity to the GLP-1 receptor for both peptides, enabling lower concentrations to achieve equivalent receptor occupancy compared to native GLP-1 [13]

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