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It is usually given once a week with or without meals at any time of day

Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

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When your mental state leads to weight gain, and that weight gain, in turn, makes you feel worse about yourself, it creates a feedback loop that can feel catastrophic

(in the T2DM group) not only enjoyed weight loss and less hunger without calorie counting but were also able to discontinue some of their diabetes medication [84]