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Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(736) amide

No head-to-head randomized controlled trial comparing Retatrutide vs Tirzepatide directly has been published as of 2026, making direct efficacy comparisons inferential based on cross-trial data

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Highlights: GLP-1 receptor agonists linked to 14 percent lower risk of developing substance use disorders Reduced risks observed across alcohol, cannabis, cocaine, nicotine and opioid disorders Patients with existing addiction experienced fewer overdoses, hospitalizations and deaths GLP-1 receptor agonist drugs commonly prescribed for type 2 diabetes mellitus and obesity may also be linked to lower risk of substance use disorders (SUD) , according to a large cohort study published in the journal BMJ (1 Trusted Source Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study