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Similarly, in a pooled analysis of results with semaglutide, a significant improvement was found in the annual impairment of eGFR, which was particularly pronounced in those with a baseline eGFR between 30 and 60 ml/min., but which remained significant in those with a higher baseline eGFR [30]

Slower dose titration may also reduce risk by producing more gradual weight loss (less metabolic stress on hair follicles)

NEWS Obesity-drug pioneers win prestigious Lasker Award for medical science Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access 199,00 per year only 3,83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout doi: References Kieffer, T

Gillespie et al

By week 12, the majority of patients report that bloating is minimal or has resolved entirely, even as appetite suppression continues to support weight loss
