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Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: a phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes

Interestingly, a single amino acid modification to this tolerogenic epitope is sufficient to break tolerance and dramatically increase the immunogenicity of the peptide [9]

For other potential indications such as substance use disorders or depression, more randomized controlled trials in humans are still needed

What we seek is lasting success, which is not a temporary measure