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Package/Label Display Panel 0.25 mg Pen PACKAGE LABEL.PRINCIPAL DISPLAY PANEL NDC 0169- 4525 -14 List 452514 0.25 mg wegovy (semaglutide) injection 0.25 mg/0.5 mL Use Wegovy 1 time a week 4 Single-Dose Prefilled Pens Each pen delivers a single dose of 0.25 mg semaglutide For subcutaneous use only Single-Dose only Rx only Contains: 4 Wegovy pens, Product Literature

Activation of the 2 -adrenergic pathway is the main mechanism by which insulin secretion is inhibited by the SNS 21 hence our strategy was to activate 2 adrenergic receptors on pancreatic -cells to test if this would counteract the hypothesised decrease in SNS activity triggered by OB GLP-1R activation in WD mice

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