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It's not perfect but it reduces your risk substantially

November 2025: FDA approved expanded Zepbound (tirzepatide) indication for moderate-to-severe obstructive sleep apnea in adults with obesity, following SURMOUNT-OSA trial data showing 62.8% reduction in apnea-hypopnea index the first drug approval for sleep apnea treatment

Key points Leg cramps (especially calves and feet) are most commonly reported Nighttime cramps and post-exercise cramps appear most frequently Duration typically ranges from seconds to minutes per episode Intensity varies from mild discomfort to painful spasms that wake patients from sleep Managing muscle cramps Most Mounjaro-related muscle cramps can be effectively managed with simple strategies

The SURMOUNT-4 Trial The Most Important Study The SURMOUNT-4 randomized clinical trial is the most comprehensive study examining what happens when patients stop tirzepatide

Obesity and overweight