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Key Takeaways GLP-3RT and retatrutide are the same research compound It is a triple-receptor agonist acting on GLP-1, GIP, and glucagon receptors It is the next-generation step beyond tirzepatide (which is dual: GLP-1 + GIP) and semaglutide (which is single: GLP-1 only) Supplied as a lyophilized synthetic peptide for laboratory research use only For the full ARG Peptides incretin-family research catalog, browse the research peptide shop

Acknowledgements We acknowledge that English language were edited by professor Jiang-Zhang from Guangxi Medical University, who is jointly awarded PhD degree by University of Florence, University of Pisa and University of Siena in Italy, and professor Jun Wu from City of Hope National Medical Center of The United States of America

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After 24 h, cells were treated with 50 g ml 1 protein synthesis inhibitor cycloheximide or 10 m MG132 (SigmaAldrich) for indicated time points