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My only real fear as I take [Ozempic] long term is that some people go off the medication and then start to gain the weight back, says Danielle K

Liraglutide modulates appetite and body weight through glucagon-like peptide 1 receptor-expressing glutamatergic neurons
[DOI] [PMC free article] [PubMed] [Google Scholar] 223.Grieco M., Giorgi A., Gentile M.C., d'Erme M., Morano S., Maras B

Long-term Safety Data Long-term safety data for semaglutide indicates that it remains effective and safe for extended use