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Meanwhile, countries in Asia, such as Singapore, South Korea, and China, are rapidly expanding biologics and biosimilar manufacturing capacity, offering scalability, speed, and growing technical sophistication, often supported by strong government investment

The growing global prevalence of IBD [2] highlights the urgent need to discover new pathways and molecular targets to broaden the therapeutic arsenal available

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While this level of selectivity for DPP-8 remains low, C-alkylation of the piperazine ring was found to be the only modification method that improved DPP-9 uncoupling relative to the lead compound