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The enhanced GI effects may cause temporary water weight shifts, while the stronger appetite suppression can lead to reduced food intake that shows up as an artificially steep drop on the scale

The convenience gains are real, but the dose adjustments need to be handled carefully to maintain the same level of metabolic benefit and appetite suppression you are accustomed to

In the SURMOUNT-5 head-to-head trial, tirzepatide achieved 20.2% average weight loss versus 13.7% for semaglutide over 72 weeks

Do not store Zepbound under the air vent of your refrigerator as that may cause freezing

The researchers limited their analysis to participants who regularly interacted with the health care system the year before getting their injectable weight loss medication