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But their use remains controversial, particularly for primary prevention (people without established heart disease)

Hargrove DM, Alagarsamy S, Croston G, Laporte R, Qi S, Srinivasan K, et al

The Big Picture On November 6, 2025 , new agreements with Eli Lilly and Novo Nordisk were announced to improve pricing and access for GLP1 medications

Common side effects of compounded semaglutide include gastrointestinal-related side effects (nausea, vomiting, constipation, diarrhea, and stomach pain) that go away in a few days or weeks

Wegovy also carries an additional indication for reducing the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease who are overweight or obese