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Description
After one half-life, 50% remains
Nevertheless, insofar as the physiological, postprandial GLP1 release from L cells is concerned, gutderived GLP1 might not reach the CNS at all, but primarily acts locally in a paracrine fashion, activating GLP1 receptors in the vicinity of the intestinal system (Richards et al., 2014)
These combined factors position semaglutide as the preferred GLP-1 therapy for home-administered obesity treatment
Titta, L., Trinei, M., Stendardo, M., Berniakovich, I., Petroni, K., Tonelli, C., Riso, P., Porrini, M., Minucci, S., Pelicci, P
2:885-893 [PubMed: 25190523] 413
