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Choose tirzepatide if: GI tolerance is a primary concern and you want lower nausea and vomiting rates
(2) gavage fed a glucose solution corresponding to the concentration described in the mixed meal diet (2 g of glucose in 23 g of Nutricia, Fortimel)

Direct modulation of the HPO axis remains a hypothesis that requires further validation through mechanistic trials

Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bhm M, BrunnerLa Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Pia IL, Packer M

R., Aune D., et al., Body Mass Index and Survival in Women With Breast CancerSystematic Literature Review and MetaAnalysis of 82 FollowUp Studies, Annals of Oncology 25 (2014): 19011914
