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Conclusions Once-weekly semaglutide 0.5 mg and 1 mg were considered dominant (more effective and less costly) versus sitagliptin 100 mg and dulaglutide 1.5 mg for the treatment of patients with type 2 diabetes with inadequate glycemic control on oral anti-hyperglycemic medications and are likely to be a good use of healthcare resources in the Spanish setting.

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The cAMP-mediated PKA/extracellular signal-regulated kinase (ERK) pathway also contributes to the regulation of antioxidant enzymes, which in turn aids in the prevention of skin aging

Glucagon increases blood glucose levels, particularly during fasting, and facilitates the mobilization of energy reserves.Synthetic agonists like semaglutide and tirzepatide are stable peptides that specifically activate the receptors of these hormones, amplifying their beneficial effects on glycemic control and weight management