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Obesity affects over 1.9 billion people worldwide.[1]In 2024, global spend on anti-obesity medication exceeded $30 billion for the first time, which is over a ten-fold increase since 2020, as reported by IQVIA.[2]This is driven by an unprecedented and ever-increasing demand for appetite-suppressing drugs, with Novo Nordisk being a leader in the research, development and manufacture []

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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.