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*Correspondence: Yue Chen, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1016/j.diabet.2014.10.005

Endotoxin testing uses the Limulus Amebocyte Lysate (LAL) assay, which measures contamination in Endotoxin Units (EU)

Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

13 GLP-1 reduces the expression of proinflammatory cytokines like CXCL-10, STAT-3, Mcp-1 and TNF-
