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Ann Intern Med 137:2533

June 15, 2021

When combined with GLP-1 agonism, glucagon receptor activation increases energy expenditure through thermogenesis, enhances fat oxidation and breakdown, improves metabolic rate in ways that counteract the metabolic slowdown typically accompanying weight loss, and may provide additional central appetite regulation

Aging per se is an independent risk factor for cholesterol gallstone formation in gallstone susceptible mice

GLP-1 receptor agonists , by substantially improving insulin sensitivity and reducing postprandial glucose excursions, lower the ambient insulin and IGF-1 environment effectively reducing a critical fuel source exploited by malignant cells