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Further Reading Wegovy Shortage: Drug Maker Limits DistributionHeres When Supplies Should Improve (Forbes)

Exendin-4 has been shown to reduce advanced glycation end product (AGE)-induced interleukin (IL)-6 and TNF- production, the expression of receptor for AGE (RAGE), and cell death in mesangial cells (Chang et al., 2017)

Lilly describes retatrutide as investigational and not FDA-approved, and says it is currently available only to participants in Lilly-sponsored clinical trials

Available as injectable, oral tablet and sublingual liquid

This expansion will create new opportunities and require manufacturers to adapt their R&D and production capabilities to meet diverse therapeutic needs