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Clinical research on HFrEF patients shows that GLP-1 agonists enhance left ventricular ejection fraction (LVEF) while reducing fibrosis according to preclinical investigations although clinical trial data for liraglutide remains neutral in FIGHT and LIVE [59,60]

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It also warned that patients should be asked about whether they are taking GLP-1 or dual GIP/GLP-1 RAs, as there is a possibility that patients may have purchased GLP-1 or dual GIP/GLP-1 RAs for aesthetic weight loss and may not readily disclose this information unless directly asked