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2013;25(4):346e255

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications that were initially approved to treat Type 2 diabetes

A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease

Written by Samantha Farpour, L26 Introduction One-in-eight, or about 13%, of American adults have used a GLP-1 receptor agonist drug (GLP-1 RA), with higher percentages of younger adults using the drugs primarily for weight loss as compared to adults ages sixty-five years and older

Histamine from mast cell degranulation directly stimulates norepinephrine release, creating a feedback loop that maintains the hyperadrenergic state