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Insulin glargine administered at pre-breakfast or at pre-dinner (both once daily) resulted in similar reductions in HbA1c compared to that with bedtime administration (see Table 12)

Its unclear if observed fractures relate more to rapid fat loss than to a direct pharmacologic effect

Individual responses and risks can vary, and only a licensed healthcare professional can evaluate appropriateness, safety, contraindications, interactions, and monitoring needs in any therapeutic setting

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