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Dual incretins (tirzepatide) target both GLP-1 and GIP hormones for stronger appetite control

Retatrutide is an investigational GIP, GLP-1, and glucagon receptor triple agonist without current MHRA approval

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19% in placebo arm, p = 0.001), but no improvement in fibrosis (p = 0.24).25 There have also been subsequent safety concerns regarding the use of vitamin E, as data suggest a possible increased risk of overall mortality and higher rates of prostate cancer, though this remains controversial.[26], [27], [28] The insulin sensitiser pioglitazone, a thiazolidinedione, has been well studied and prescribed by some for the treatment of NASH, usually in line with diabetic practice guidelines

Engaging with a healthcare provider who considers individual challengessuch as cultural dietary habits, work-related fatigue, or family responsibilitiesmay support more sustainable weight loss outcomes