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In a study investigated whether miRNAs affect GLP-1's glucose-stimulated insulin release, authors measured miRNA levels in rat insulinoma cell line (INS-1) cells and isolated islets from GLP-1-treated rats and humans using osmotic pumps in vitro and in vivo

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Similarly, severe abdominal pain, particularly if localized to the upper abdomen and radiating to the back, warrants immediate assessment to rule out pancreatitisa rare but serious potential adverse effect of GLP-1 medications

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