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Meanwhile, a study that used data from over 520,000 patients suggests that those who started taking a GLP-1 (such as Zepbound) to manage their Type 2 diabetes had a higher rate of developing NAION within one year than the control group

Furthermore, sodium and potassium-dependent ATP activity, a key marker of CSF secretion, was reduced [103]

Victoza (liraglutide), the first GLP-1 for type 2 diabetes to lose exclusivity in June 2024, may not generate significant savings due to its once-daily dosing and limited market share

This is exactly what you would expect from a drug whose cardiac effects are driven by receptor activation, more drug means more receptor binding means more cAMP means faster heart rate

Research gaps Despite considerable progress, important research gaps remain