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Int J Obes 39 , 834841 (2015)

9 Given the increasing offlabel use of GLP1RAs for weight management and the high prevalence of psychiatric comorbidities among individuals with metabolic disease, evaluating their neuropsychiatric safety and therapeutic potential is essential

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Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]