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The paw withdrawal latency (PWL) to heat was measured after either intraperitoneal or oral gavage administration of glucose (2.0 g/kg body weight) in a volume of 200 L or the same volume of vehicle (0.9% saline) ( n = 5 per group)

While its full safety profile is still being established in Phase 3 trials, initial data from Phase 2 trials suggest that retatrutide is generally well-tolerated

2019;179(5):11291143.e23
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