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10.1016/j.euroneuro.2014.06.008 Eur
Une cible de traitement serait donc de rtablir ces fonctions
APOE 2 and APOE 3 mediate rapid A clearance by interacting with LRP-1, whereas APOE 4 has a higher affinity to very low-density lipoprotein receptor (VLDR) resulting in slower clearance of A and increased accumulation in the brain (van Assema et al., 2011)
