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Gastrointestinal tract Delayed gastric emptying increases satiety, blunts postprandial spikes, and reduces overall energy intake

In addition, the limitations of GLP-1R agonist therapy, which may cause gastrointestinal adverse effects and significantly alter the patients physiological state, make it not widely applicable to all patients

In a 2023 systematic review of the effectiveness of several obesity medications, semaglutide achieved the greatest mean weight loss, a finding that was echoed in a 2022 JAMA paper comparing semaglutide with liraglutide (figure 4) .* There is evidence to suggest that tirzepatide, currently approved for use as a diabetes medication but not yet as a weight loss drug, is superior still to semaglutide

The drug has a long half-life, which means it can be administered monthly or less frequently, giving the drug the potential to improve adherence and long-term weight control, according to Jay Bradner, executive vice president of research and development at Amgen