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There genetic and phenotypic differences highlight the importance of personalized risk assessment and tailored therapeutic approaches in DKD [34,35]

Statistical Analysis Data are expressed as means standard error of the mean (SE)

Viral proteins, particularly the hepatitis B virus X protein (HBx), act as an important positive regulator for gluconeogenesis ( de novo lipogenesis ( Thus, for viral etiologies, the virus acts as the initial trigger, but the resulting metabolic dysregulation and chronic inflammatory state which overlaps significantly with the pathophysiology of MASLD are focused on and ultimately destroy the livers tissue architecture, creating the sustained carcinogenic environment ( 4 Current therapeutic landscape and unmet need While resmetirom (a THR- agonist) has recently gained FDA approval for the treatment of MASH (in patients with fibrosis F2-F3), marking the first-ever pharmacological agent for this condition ( Management of the underlying SLDs typically revolves around etiology-specific interventions: lifestyle modifications (diet, exercise, and weight loss) are the cornerstone for MASLD/MASH