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Organ crosstalk in bariatric surgery Beyond effects on insulin sensitivity and secretion, bariatric surgery leads to physiological changes across multiple organ systems that could also contribute to improvements in whole-body glucose metabolism

Incretin-based antidiabetic therapies, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), may offer benefits for individuals at risk of neurodegeneration due to their central effects on appetite and satiety regulation via the hypothalamus ( While GLP-1 is primarily synthesized and secreted by intestinal L-cells in response to nutrient intake, it is also produced in the brain, particularly in the nucleus of the solitary tract in the brainstem

Rapid caloric restriction can affect serotonin production, since the amino acid tryptophan (a serotonin precursor) comes from dietary protein

Keep the cap on the pen to protect the medicine from light

Study protocol and redacted clinical study report will be available according to Novo Nordisk data sharing commitments