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10.3389/fendo.2018.00672 63 RubinoD

Clinical Guideline CG97

GLP-1RA may influence the activity of two opposite subgroup neurons within ARC, which are related to food intake and body weight, containing proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) and neuropeptide Y/agouti related peptide (NPY/AgRP) neurons

This prevents both the hungry nausea that comes from empty stomachs and the overfull nausea that comes from large meals sitting too long

Previous assumptions held that these medications wouldnt directly affect liver enzymes since GLP-1 receptors arent present in significant quantities on hepatocytes (liver cells)