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Unsurprisingly, before the discovery and commercialization of insulin in the 1920's, juvenile-onset diabetes, with its paucity of endogenous insulin, was a disease with only a few years between a patient's diagnosis and premature demise

Simmons, Hormonal predictors of sexual motivation in natural menstrual cycles, Hormones and Behavior, Volume 63, Issue 4,2013, Pages 636-645, ISSN 0018- 506X

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This is usually attributable to the solution temperature

GLP-1 receptors are expressed in several tissues in the body, including the gastrointestinal tract, heart, lung, kidney, and brain