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Microbiota-gut-brain axis: communication pathways The MGBA acts through specific communication pathways in controlling gut functions (e.g., gut motility and secretion), activating local immune responses, modulating CNS functions (e.g., mood, and psychiatric conditions associated with stress and memory), and controlling metabolism [6]

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If 8 mg produces consistent weight loss with good tolerability, it is an excellent maintenance dose

Due to the categorical nature of the outcomes, no dose-response meta-regression analysis was performed

I can see higher-risk patients being more likely to have been given Tirzepetide, given the widely held perception that its a stronger medication if they were assessed to have greater risk and skewing the patient pool