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While 73% of Americans are either overweight or have obesity, there are open questions about the use of GLP-1s in people who are not overweight will these medications cause excess weight loss and, in particular, excess muscle loss

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As next-generation pharmacotherapies become available, clinicians must be prepared to reassess long-standing treatment targets and embrace a more ambitious, personalized approach to weight management.

Taking into account the considerable reduction in incretin effect (i.e., the secretion of insulin in response to oral glucose ingestion mediated by GLP-1 and glucose-dependent insulinotropic peptideGIP) in patients with T2DM and the significant anti-hyperglycemic action, GLP-1 RAs are strongly recommended in the management of patients with T2DM [13]