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Conclusions In conclusion, both GLP-1RA and SGLT2-i exert a myriad of cardiovascular benefits for patients with diabetes, obesity, heart failure, and chronic kidney disease

Fuemmeler, Ph.D., MPH , associate director for population sciences and the Gordon D

Amato et al 55 reported that GLP-1 receptor (GLP-1R) is expressed in the nitrergic neurons of the myenteric plexus in human colon circular muscular strips and, once activated by exogenous GLP-1, mediates an inhibitory effect on large intestinal motility through nitric oxide neural release resulting in reduction of the spontaneous contractile activity of the smooth muscles, which may contribute to delaying of intestinal propulsion to increase water and electrolyte absorption

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