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Annu Rev Nutr 2010;30:273290 [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Reaven GM

Call your doctor for medical advice about side effects

Patients may be more likely to see quicker results if they adhere to the recommended diet and exercise plan

Meta-analyses of clinical trials indicate that berberine supplementation can lead to approximately 4.5 pounds of weight loss and measurable reductions in waist circumference

It has therefore been considered suboptimal when evaluating treatment effects in clinical trials [71, 72]