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therefore, the number of participants representing efficacy findings may differ from the number representing safety findings due to different pools of study participants analyzed for efficacy and safety

Variants in GLP1R, GIPR, FTO, and MC4R may correlate with differential response patterns

A 2025 review on the effects of weight cycling on muscle and sarcopenia suggested that it may lead to disproportionate fat regain, reduced FFM, accelerated age-related muscle loss and an increased risk for functional impairment and disability, particularly in older or frail individuals, contributing to worsened muscle health outcomes including sarcopenic obesity [14]

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doi: 10.2337/ds16-0026 47 PauzaAGThakkarPTasicTFelippeIBishopPGreenwoodMPet al