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Despite these benefits, intensive glycemic control in patients with diabetes can worsen diabetic retinopathy, a phenomenon known as early worsening, which typically occurs within the first year of intensive treatment [11]

It raises heart rate in a dose-dependent way

Sequential initiationadding one agent, allowing 48 weeks for tolerance to develop, then introducing the secondmay improve tolerability, particularly regarding gastrointestinal side effects from GLP-1 receptor agonists

These medications help men feel full longer, reduce cravings, and support better portion control

The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study