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Source: Snchez-Garrido MA, et al
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Production of pro angiogenic factors such as PIGF and VEGFZ and reactive oxidative species also plays a role in endothelial disruption (95)
As such, in various mouse knockout models of the GcgR signaling system, the BW-lowering efficacy of IUB288 treatment is substantially reduced relative to the outcome seen in DIO WT mice
Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight
