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Competing interests The authors received no grants or funding for the writing of this article

PLoS ONE 12 , e0185624 (2017)

If you slip up (say, you indulged at a party or skipped workouts for a week during a vacation), the key is to not spiral into negative thinking

Yes, clinical trials show that patients typically regain significant weight after discontinuing GLP-1 medications
Excess adiposity triggers chronic low-grade inflammation, impairs insulin sensitivity, and accelerates endothelial dysfunctionall independent of subsequent weight loss
