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Current literature supports GLP-1R-mediated anti-inflammatory and neuroprotective effects in the retina 43

The content is not intended to encourage application, diagnosis, or self-treatment of unlicensed individuals, and should not be used as a substitute for the clinical judgment of a qualified healthcare provider.

GLP-1 receptors are expressed in the heart muscle cells, immune system cells in the heart, and in the lining of blood vessels.[ref] GLP-1 RAs have been shown to help in heart failure and also to have beneficial effects on heart rhythm.[ref] Related article : Cardiovascular disease genetic risk factors Cancer Research: Retatrutide, a GLP-1/GIP/GCG triple agonist, has recently been shown to reduce pancreatic tumor mass in animals

Main Outcomes and Measures On-treatment weight change in a propensity scorematched population, assessed as hazard of achieving 5% or greater, 10% or greater, and 15% or greater weight loss, and percentage change in weight at 3, 6, and 12 months
