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In support, Li et al

In the Phase 2 Lancet trial, orforglipron 45 mg reduced HbA1c by up to 2.1 percentage points at 26 weeks, exceeding the reduction achieved by dulaglutide 1.5 mg (the active comparator)
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They slow gastric emptying, improve insulin sensitivity, reduce hepatic glucose production, and appear to have direct cardiovascular benefits independent of weight loss