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For example, VSG surgery enhances resting-state functional connectivity between the hippocampus and the insula [41] and between the dorsolateral PFC and the anterior cingulate, with these outcomes accompanied by dampened cravings for high calorie foods [42] and reduced fasting levels of ghrelin [41,42]

It is a literature review on new drugs for an off-label indication

Conversely, if you are on injections but struggling with side effects, switching to drops might provide adequate results with better tolerability

While it was initially reported that mice deficient in Insl5 were mildly glucose-intolerant (170), this appears to be age (170) and strain-dependent (164, 168)