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The timing question: when to inject each compound Timing matters more for AOD 9604 than for tirzepatide, and getting this wrong can significantly reduce AOD 9604 effectiveness while having almost no impact on tirzepatide response

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Since the stomach empties more slowly on GLP-1 meds, patients who continue to eat two or three times a day often overload their gutand get the predictable nausea, bloating, and constipation that can come with that

However, these studies did not specifically include patients with kidney disease, and the numbers of hard kidney outcomes reached (i.e., kidney transplantation, initiation of maintenance dialysis, death from kidney failure, or a sustained low GFR) were too low to make definitive conclusions on the renoprotective effects of GLP-1 receptor agonists