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Other Outcomes and Subgroup Analyses (Table 2a) The incidence of cirrhosis-related complications (e.g., ascites, encephalopathy, varices) and the need for liver-specific medications were lower with semaglutide, further supporting its protective effects against hepatic decompensation

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Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28

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