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Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice

Those with severe kidney disease should also use berberine cautiously and under medical supervision, as specific guidance is limited given berberine's status as a supplement rather than a regulated pharmaceutical

Cardiovasc Diabetol 16: 6, 2017

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The effect of spironolactone on morbidity and mortality in patients with severe heart failure